Cheng Jun, Zhao Dong, Wang Wei, Li Zhi-an, Yong Qiang, Sun Jia-yi, Zhao Li-ya, Wu Zhao-su
Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital University Affiliation Beijing Anzhen Hospital, Beijing 100029, China.
Zhonghua Nei Ke Za Zhi. 2006 Mar;45(3):206-9.
To explore the association of cardiovascular disease (CVD) risk factors and its impact on the 10-year prevalence of carotid atherosclerosis.
Two surveys for CVD risk factors were carried out in a population consisting of 1323 subjects in Beijing in both 1992 and 2002 and a direct measurement of carotid arteries with B-mode ultrasound imaging were performed in 2002. Intima-media thickness (IMT) and plaque of carotid arteries were regarded as the indicators of carotid atherosclerosis and main CVD risk factors were treated as the impact factors.
(1) 10-year prevalence of carotid atherosclerosis continually increased with elevated baseline risk factors levels. Age, smoking, hypertension and hypercholesterolemia were found to be independently associated with carotid atherosclerosis. (2) 10-year prevalence of carotid atherosclerosis increased with the elevated number of risk factors clustering in individuals. (3) The prevalence of IMT and plaque were 67.1% and 42.6% in subjects with CVD risk factors in both 1992 and 2002 surveys with Odds Ratios being 1.7 and 3.1 times as those without risk factors.
Traditional CVD risk factors exert impact on CVD and carotid atherosclerosis with different degrees and carotid atherosclerosis can be regarded as an early evaluation indicator for risk of atherosclerotic diseases.
探讨心血管疾病（CVD）危险因素及其与颈动脉粥样硬化10年患病率的关联。
1992年和2002年对北京地区1323名受试者进行了两次心血管疾病危险因素调查，并于2002年采用B型超声成像直接测量颈动脉。将颈动脉内膜中层厚度（IMT）和斑块作为颈动脉粥样硬化的指标，将主要心血管疾病危险因素作为影响因素。
（1）颈动脉粥样硬化的10年患病率随基线危险因素水平升高而持续增加。年龄、吸烟、高血压和高胆固醇血症被发现与颈动脉粥样硬化独立相关。（2）颈动脉粥样硬化的10年患病率随个体中危险因素聚集数量的增加而升高。（3）在1992年和2002年的调查中，有心血管疾病危险因素的受试者中IMT和斑块的患病率分别为67.1%和42.6%，优势比分别是无危险因素者的1.7倍和3.1倍。
传统心血管疾病危险因素对心血管疾病和颈动脉粥样硬化有不同程度的影响，颈动脉粥样硬化可作为动脉粥样硬化性疾病风险的早期评估指标。
