Serra Montserrat, Gastó Cristóbal, Navarro Víctor, Torres Xavier, Blanch Jordi, Masana Guillem
Instituto Clínico de Psiquiatría y Psicología, Hospital Clínic, Universidad de Barcelona, Barcelona, Spain.
Med Clin (Barc). 2006 Apr 8;126(13):491-2. doi: 10.1157/13086850.
This study was designed to assess the safety and efficacy of continuation/maintenance electroconvulsive therapy (ECT) in elderly psychotic major depressed patients after ECT remission.
Using a longitudinal randomized single-blind design, we compared the two-year outcome of two subgroups of psychotic unipolar depressed elderly patients who were ECT remitters: one treated with a maintenance nortriptyline regimen (n = 13) and one treated with combined maintenance ECT plus nortriptyline (n = 6).
During 2 years of maintenance treatment in elderly psychotic unipolar depressed ECT remitters, relapse/recurrence rates were significantly higher in the nortriptyline subgroup than in the combined ECT plus nortriptyline subgroup. The tolerability of both treatments was similar.
This study supports the use of combined maintenance ECT and antidepressant treatment in elderly psychotic unipolar depressed patients who are ECT remitters.
本研究旨在评估延续性/维持性电休克治疗（ECT）对老年重度抑郁性精神病患者ECT缓解后的安全性及有效性。
采用纵向随机单盲设计，我们比较了两组ECT缓解的单相抑郁老年精神病患者的两年预后：一组接受去甲替林维持治疗方案（n = 13），另一组接受ECT联合去甲替林维持治疗（n = 6）。
在老年单相抑郁性精神病ECT缓解患者的2年维持治疗期间，去甲替林亚组的复发率显著高于ECT联合去甲替林亚组。两种治疗的耐受性相似。
本研究支持对ECT缓解的老年单相抑郁性精神病患者采用ECT联合抗抑郁药维持治疗。
