Yang Hongyan, Chopp Michael, Jiang Feng, Zhang Xuepeng, Schallert Timothy
Institute for Neuroscience and Department of Psychology, University of Texas at Austin, 1 University Station, #A8000, Austin, TX 78712, USA.
Exp Neurol. 2006 Jul;200(1):262-6. doi: 10.1016/j.expneurol.2006.02.007. Epub 2006 Apr 19.
Glutamate antagonists have recently been shown to limit tumor growth, providing potential new therapeutic targets and strategies against brain tumors. Here, we demonstrate that the glutamate NMDA receptor antagonist MK801, after a delay, adversely reverses functional recovery in rats with compressive mass lesions of the sensorimotor cortex. Our data suggest that the controlled focal cortical compression model may be a valuable pre-clinical tool to screen compounds for the treatment of brain tumors. It may be possible to use this model to develop interventions that maintain anti-cancer effects but with diminished harm to bystander tissue and brain plasticity.
谷氨酸拮抗剂最近已被证明可限制肿瘤生长，为对抗脑肿瘤提供了潜在的新治疗靶点和策略。在此，我们证明谷氨酸N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK801在延迟给药后，会对患有感觉运动皮层压迫性肿块病变的大鼠的功能恢复产生不利的逆转作用。我们的数据表明，可控性局灶性皮质压迫模型可能是一种有价值的临床前工具，用于筛选治疗脑肿瘤的化合物。利用该模型开发既能维持抗癌效果，又能减少对周围组织和脑可塑性损害的干预措施或许是可行的。
