Gencer Mehmet, Ceylan Erkan, Yilmaz Remzi, Gur Mustafa
The Department of Chest Disease, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
Respir Med. 2006 Nov;100(11):1933-43. doi: 10.1016/j.rmed.2006.03.006. Epub 2006 Apr 19.
Diffuse systemic-pulmonary anastomoses and chronic hypoxemia may result in increase in ventricular work in bronchiectasis. We aimed to assess right ventricular (RV) and left ventricular (LV) functions in patients with bronchiectasis by using tissue Doppler-derived myocardial performance index (MPI), which is a novel and more sensitive parameter than conventional ventricular function parameters. To assess the possibility of RV and LV dysfunctions occurring in bronchiectasis, we studied 25 patients with bronchiectasis, and compared them with 22 age- and gender-matched control subjects. MPI, which is a combined index of both systolic and diastolic ventricular function, was calculated for both ventricles. RV and LV MPIs were also significantly different in patients and the controls. RV MPI was associated with the number of involved lobe, arterial blood oxygen pressure, and acceleration time/ejection time of pulmonary flow. LV MPI was not related to any clinical parameter, but it was correlated only with RV MPI. Ventricular functions are impaired in bronchiectasis. The impairment of RV function is related to involved lung lobe number, arterial oxygen pressure, and acceleration time/ejection time of pulmonary flow. LV dysfunction was correlated only with RV function.
弥漫性体肺分流和慢性低氧血症可能导致支气管扩张症患者心室做功增加。我们旨在通过使用组织多普勒衍生的心肌性能指数（MPI）来评估支气管扩张症患者的右心室（RV）和左心室（LV）功能，该指数是一种比传统心室功能参数更新颖、更敏感的参数。为了评估支气管扩张症患者发生RV和LV功能障碍的可能性，我们研究了25例支气管扩张症患者，并将他们与22名年龄和性别匹配的对照受试者进行比较。计算了两个心室的MPI，它是心室收缩和舒张功能的综合指标。患者和对照组的RV和LV MPI也有显著差异。RV MPI与受累肺叶数量、动脉血氧分压以及肺血流加速时间/射血时间相关。LV MPI与任何临床参数均无关，但仅与RV MPI相关。支气管扩张症患者的心室功能受损。RV功能受损与受累肺叶数量、动脉血氧分压以及肺血流加速时间/射血时间有关。LV功能障碍仅与RV功能相关。
