通过固相支持甲基化同时生产¹¹C标记示踪剂的简易自动化系统。
Simple automated system for simultaneous production of 11C-labeled tracers by solid supported methylation.
作者信息
Quincoces Gemma, Peñuelas Iván, Valero Marta, Serra Patricia, Collantes María, Martí-Climent Josep, Arbizu Javier, García-Velloso María José, Richter José Angel
机构信息
Department of Nuclear Medicine, University Hospital, University of Navarra School of Medicine, Av. Pío XII 36,31008 Pamplona, Spain.
出版信息
Appl Radiat Isot. 2006 Jul;64(7):808-11. doi: 10.1016/j.apradiso.2006.03.001. Epub 2006 Apr 18.
We herein describe a simple setup for the automated simultaneous synthesis of L-[methyl-11C]methionine and N-[methyl-11C]choline by solid-supported methylation. The setup is extremely simple and easy to adapt to other automated systems and due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation step. Furthermore, it can be used for multiple simultaneous synthesis.
我们在此描述了一种通过固相支持甲基化自动同时合成L-[甲基-11C]蛋氨酸和N-[甲基-11C]胆碱的简单装置。该装置极其简单，易于适配其他自动化系统，并且由于其通用性，该方法可用于生产其他需要简单[11C]甲基化步骤的放射性药物。此外，它可用于多个同时合成。
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