Nakano Seigo, Asada Takashi, Yamashita Fumio, Kitamura Noriko, Matsuda Hiroshi, Hirai Shigeo, Yamada Tatsuo
Fifth Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.
Neuroimage. 2006 Aug 1;32(1):301-6. doi: 10.1016/j.neuroimage.2006.02.040. Epub 2006 Apr 19.
To examine the relationship between antisocial behaviors and reduction of regional cerebral blood flow (rCBF) in patients with frontotemporal dementia (FTD).
Brain perfusion single photon emission computed tomography (SPECT) was performed in 22 patients with FTD and 76 age-matched healthy volunteers. The statistical analysis was conducted using the SPM99 software. The antisocial behavioral symptoms were assessed independently by three geriatric psychiatrists, who had not been given the information of the SPECT images.
Compared with normal controls, FTD patients showed significant reduction of rCBF in the widespread frontal cortical areas. The correlation analysis showed that antisocial behavioral symptoms are associated with reduction of rCBF in the orbitofrontal cortex.
The functional decline of orbitofrontal cortex is related to antisocial behavioral symptoms in patients with FTD.
研究额颞叶痴呆（FTD）患者的反社会行为与局部脑血流量（rCBF）减少之间的关系。
对22例FTD患者和76名年龄匹配的健康志愿者进行脑灌注单光子发射计算机断层扫描（SPECT）。使用SPM99软件进行统计分析。由三位老年精神科医生独立评估反社会行为症状，他们未被告知SPECT图像信息。
与正常对照组相比，FTD患者在广泛的额叶皮质区域rCBF显著减少。相关分析表明，反社会行为症状与眶额皮质rCBF减少有关。
眶额皮质功能衰退与FTD患者的反社会行为症状有关。
