香叶基香叶基丙酮，一种热休克蛋白70的诱导剂，可减轻睡眠剥夺后的快速眼动睡眠反弹。

Geranylgeranylacetone, an inducer of HSP 70, attenuates REM sleep rebound after sleep deprivation.

作者信息

Wada Tadashi, Sei Hiroyoshi, Kusumoto Kenji, Kitaoka Kazuyoshi, Chikahisa Sachiko, Rokutan Kazuhito, Morita Yusuke

机构信息

Department of Integrative Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.

出版信息

Brain Res Bull. 2006 Apr 28;69(4):388-92. doi: 10.1016/j.brainresbull.2006.02.004. Epub 2006 Mar 3.

DOI:10.1016/j.brainresbull.2006.02.004

PMID:16624670

Abstract

The effect of pretreatment of geranylgeranylacetone (GGA), an inducer of heat shock protein (HSP) 70, on responses in sleep and core body temperature (Tcore) against sleep deprivation (SD) was examined in rats. After 3 days of GGA or vehicle injection, a 6-h period of SD was performed. During the recovery period, both rapid-eye movement (REM) and non-REM (NREM) sleep were increased in both GGA- and vehicle-injected rats. However, in GGA-injected rats, REM-sleep rebound was significantly suppressed, while NREM-sleep rebound remained unaffected. In addition, the increase of Tcore caused by SD was also attenuated in GGA-injected rats. In the hippocampus, both SD and the GGA pretreatment induced an increase in the expression of HSP70 mRNA, indicating that the SD functions as a stress for hippocampal neurons and that the GGA induces HSP70 expression. The findings suggest that pretreatment with GGA suppresses REM sleep rebound and the response of Tcore against SD.

摘要

在大鼠中研究了热休克蛋白（HSP）70诱导剂香叶基香叶基丙酮（GGA）预处理对睡眠剥夺（SD）后睡眠和核心体温（Tcore）反应的影响。在注射GGA或赋形剂3天后，进行6小时的睡眠剥夺。在恢复期，注射GGA和赋形剂的大鼠快速眼动（REM）睡眠和非快速眼动（NREM）睡眠均增加。然而，在注射GGA的大鼠中，REM睡眠反弹受到显著抑制，而NREM睡眠反弹未受影响。此外，注射GGA的大鼠中由睡眠剥夺引起的Tcore升高也有所减弱。在海马体中，睡眠剥夺和GGA预处理均诱导HSP70 mRNA表达增加，表明睡眠剥夺对海马神经元起到应激作用，且GGA诱导HSP70表达。研究结果表明，GGA预处理可抑制REM睡眠反弹以及Tcore对睡眠剥夺的反应。