[Sodium transport and its regulation of acutely isolated alveolar type II cells].
作者信息
Shen Hai-yan, Li Tao-ping
机构信息
Department of Respiratory Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2006 Apr;26(4):476-8.
PMID:16624757
Abstract
OBJECTIVE
To observe the sodium current of acutely isolated alveolar type II cells and its regulation.
METHODS
After isolation the AT II cells, the whole cell sodium current were recorded in 5 hours with patch-clamp in whole-cell mode, and the effect of amiloride and terbutaline on the current was investigated.
RESULTS
The amiloride-sensitive current of AT II cells were recorded, which could be obviously stimulated by terbutaline.
CONCLUSION
Acutely isolated AT II cells can be valuable for studying electrophysiological characteristics of sodium channels even under pathological conditions.
摘要
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