[脂肪乳剂对改善严重烧伤患者蛋白质丢失的作用]

[Effect of intralipid for ameliorating protein loss in severe burned patients].

作者信息

Rong Xin-zhou, Zhang Tao, Li Qing-hui, Yang Rong-hua, Hua Rong, Huang Xiao-hua

机构信息

Department of Burn, First People's Hospital of Guangzhou, Guangzhou 510180, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2006 Apr;26(4):500-1.

PMID:16624765

Abstract

OBJECTIVE

To investigate the effect of intralipid on protein consumption in severe burned patients. METHODS; Sixty-seven nonoperative patients with severe burns were divided into Intralipid treatment group and non-intralipid treatment group (control group), and the former was treated with 20% intralipid (500 ml once a day) from postburn day 4 for 10 consecutive days. Venous blood samples were collected from these patients for testing total protein, albumin, total cholesterol and triglyceride on postburn days 1, 7 and 14, respectively.

RESULTS

The levels of total protein, albumin, total cholesterol and triglyceride were within normal range on postburn day 1 in both groups, and only the albumin level was lowered in the groups on day 7 but at comparable magnitudes (32+/-4.83 vs 31+/-5.04 g/L, P<0.05). In contrast, the levels of total protein, albumin, total cholesterol and triglyceride were below the normal range on postburn day 14 in both groups, but intralipid treatment group showed more albumin loss than the control group (28+/-6.46 vs 23+/-7.03 g/L, P<0.01).

CONCLUSION

Intralipid (20%) provides good energy source to ameliorate albumin loss in severe burned patients.

摘要

目的

探讨脂肪乳剂对重度烧伤患者蛋白质消耗的影响。方法：将67例非手术治疗的重度烧伤患者分为脂肪乳剂治疗组和非脂肪乳剂治疗组（对照组），脂肪乳剂治疗组于伤后第4天开始每日给予1次20%脂肪乳剂（500 ml），连续使用10天。分别于伤后第1、7和14天采集两组患者静脉血检测总蛋白、白蛋白、总胆固醇和甘油三酯。

结果

两组患者伤后第1天总蛋白、白蛋白、总胆固醇和甘油三酯水平均在正常范围内，仅伤后第7天两组患者白蛋白水平均降低，但降低幅度相当（32±4.83 vs 31±5.04 g/L，P<0.05）。相比之下，两组患者伤后第14天总蛋白、白蛋白、总胆固醇和甘油三酯水平均低于正常范围，但脂肪乳剂治疗组白蛋白丢失较对照组更多（28±6.46 vs 23±7.03 g/L，P<0.01）。