Tan H-W, Li L, Zhang W, Ma Z-Y, Zhong X-Z, Zhang Y
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan, China.
J Hum Hypertens. 2006 Aug;20(8):618-24. doi: 10.1038/sj.jhh.1002030. Epub 2006 Apr 20.
Tissue Doppler Tei index is pointed to be more effective in the evaluation of global cardiac function than systolic and diastolic measurements alone in various heart diseases. This study was designed to assess the effect of cilnidipine on left ventricular function in hypertensive patients by using this index. A group of 40 hypertensives (mean age 55+/-8 years, range: 35-65) and 16 controls (mean age 52+/-9 years, range: 36-65) were included. Hypertensives were classified into non-left ventricular hypertrophy (NLVH) group (25 patients) and left ventricular hypertrophy (LVH) group (15 patients), and treated with cilnidipine for 2 months. Before and after treatment, the participants were examined by echocardiography. Tissue Doppler Tei index was calculated as diastolic time interval measured from end of late diastole to origin of early diastole (a') minus systolic Sm duration (b') divided by b', that is Tei index = (a'-b')/b'. Thirty-seven hypertensive patients finished the treatment. Tei index was significantly higher in NLVH and LVH groups than in control group, and in LVH group than in NLVH group (0.44+/-0.07 vs 0.28+/-0.06, P < 0.001; 0.51+/-0.13 vs 0.28+/-0.06, P < 0.001; 0.51+/-0.13 vs 0.44+/-0.07, P < 0.05). After treatment, Tei index was significantly decreased (0.40+/-0.11 vs 0.46+/-0.10, P < 0.0001); systolic blood pressure and diastolic blood pressure were also decreased significantly. In conclusion, Tei index is impaired in hypertensives before development of ventricular hypertrophy and impairment is more prominent in hypertrophy. Cilnidipine can improve left ventricular function. Tissue Doppler Tei index is gaining importance in evaluating LV function after drug intervention in hypertensive patients.
组织多普勒Tei指数在评估各种心脏病的整体心功能方面，被认为比单独的收缩期和舒张期测量更有效。本研究旨在通过使用该指数评估西尼地平对高血压患者左心室功能的影响。纳入了一组40名高血压患者（平均年龄55±8岁，范围：35 - 65岁）和16名对照者（平均年龄52±9岁，范围：36 - 65岁）。高血压患者被分为非左心室肥厚（NLVH）组（25例患者）和左心室肥厚（LVH）组（15例患者），并接受西尼地平治疗2个月。治疗前后，通过超声心动图对参与者进行检查。组织多普勒Tei指数计算为从舒张末期结束到舒张早期起始测量的舒张时间间隔（a'）减去收缩期Sm持续时间（b'）再除以b'，即Tei指数 = (a' - b')/b'。37名高血压患者完成了治疗。NLVH组和LVH组的Tei指数显著高于对照组，且LVH组高于NLVH组（0.44±0.07对0.28±0.06，P < 0.001；0.51±0.13对0.28±0.06，P < 0.001；0.51±0.13对0.44±0.07，P < 0.05）。治疗后，Tei指数显著降低（0.40±0.11对0.46±0.10，P < 0.0001）；收缩压和舒张压也显著降低。总之，在心室肥厚发生之前，高血压患者的Tei指数受损，且在肥厚时损害更明显。西尼地平可改善左心室功能。组织多普勒Tei指数在评估高血压患者药物干预后的左心室功能方面正变得越来越重要。
