双相I型障碍、强迫症或二者皆有的患者的临床结局。
Clinical outcome in patients with bipolar I disorder, obsessive compulsive disorder or both.
作者信息
Centorrino Franca, Hennen John, Mallya Gopinath, Egli Samy, Clark Tim, Baldessarini Ross J
机构信息
Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont 02478, and Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA.
出版信息
Hum Psychopharmacol. 2006 Apr;21(3):189-93. doi: 10.1002/hup.760.
BACKGROUND
Bipolar disorder (BPD) is often comorbid with obsessive-compulsive (OCD) and other anxiety disorders, but the impact of such comorbidity on long-term outcome has not been evaluated systematically.
METHODS
Extensive follow-up assessments were carried out at 4.3 years after index hospitalizations in a mixed BPD-OCD group (N=20) compared to matched groups with BPD (N=22) or OCD (N=20) alone.
RESULTS
At follow-up, ratings of functional status were similar across groups. Rehospitalizations were similar among BPD-OCD and BPD subjects, but 2.9-times more frequent among comorbid than OCD patients. OCD symptoms averaged 150% more severe in OCD than comorbid subjects, and were not measured in BPD subjects.
CONCLUSIONS
Despite potential sampling bias with previously hospitalized subjects, the findings suggest that comorbid BPD-OCD patients may be clinically more similar to BPD than OCD patients, and that BPD-OCD comorbidity may not negatively impact the long-term clinical outcome.
背景
双相情感障碍（BPD）常与强迫症（OCD）及其他焦虑症共病，但这种共病对长期预后的影响尚未得到系统评估。
方法
在混合性双相情感障碍-强迫症组（N = 20）的首次住院4.3年后进行了广泛的随访评估，并与单纯双相情感障碍组（N = 22）或单纯强迫症组（N = 20）进行匹配比较。
结果
随访时，各组的功能状态评分相似。双相情感障碍-强迫症组和双相情感障碍组的再住院率相似，但共病组的再住院率是强迫症患者的2.9倍。强迫症患者的强迫症状平均比共病患者严重150%，双相情感障碍患者未测量强迫症状。
结论
尽管既往住院患者可能存在抽样偏差，但研究结果表明，双相情感障碍-强迫症共病患者在临床上可能与双相情感障碍患者比与强迫症患者更相似，且双相情感障碍-强迫症共病可能不会对长期临床预后产生负面影响。
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