肥厚型心肌病中的血清肌酸激酶MM同工酶

Serum creatine kinase MM isoforms in hypertrophic cardiomyopathy.

Hamada M, Ohtani T, Sekiya M, Fujiwara Y, Sumimoto T, Hiwada K, Morita S, Tsukada H

2nd Department of Internal Medicine, Ehime University School of Medicine, Japan.

Clin Sci (Lond). 1991 Dec;81(6):723-6. doi: 10.1042/cs0810723.

Abstract

To determine whether a persistent release of creatine kinase from the myocardium occurs in patients with hypertrophic cardiomyopathy, the activities of serum creatine kinase MM isoforms were measured in 22 patients with hypertrophic cardiomyopathy and in 14 normal control subjects. 2. Serum creatine kinase MB activity was significantly higher in patients with hypertrophic cardiomyopathy (7.8 +/- 3.8 i.u./l) than in normal control subjects (0.4 +/- 0.8 i.u./l; P less than 0.01). 3. Serum MMa, MMb and MMc activities in patients with hypertrophic cardiomyopathy were 19.4 +/- 4.1%, 26.7 +/- 2.5% and 33.5 +/- 7.0% of the total creatine kinase MM activity, respectively. These values for each isoform were significantly different from those in normal control subjects (11.3 +/- 3.0%, 21.5 +/- 4.4% and 40.7 +/- 7.0%, respectively). The MMa/MMc activity ratio was significantly higher in patients with hypertrophic cardiomyopathy (0.61 +/- 0.25) than in normal control subjects (0.30 +/- 0.10; P less than 0.01). 4. Our results indicate that a small amount of the myocardial tissue isoform of creatine kinase MM (MMa) is constantly released in many patients with hypertrophic cardiomyopathy.

摘要

为了确定肥厚型心肌病患者心肌中是否存在肌酸激酶的持续释放，我们检测了22例肥厚型心肌病患者和14例正常对照者血清肌酸激酶MM同工酶的活性。2. 肥厚型心肌病患者血清肌酸激酶MB活性（7.8±3.8国际单位/升）显著高于正常对照者（0.4±0.8国际单位/升；P<0.01）。3. 肥厚型心肌病患者血清MMa、MMb和MMc活性分别占总肌酸激酶MM活性的19.4±4.1%、26.7±2.5%和33.5±7.0%。各同工酶的这些值与正常对照者（分别为11.3±3.0%、21.5±4.4%和40.7±7.0%）显著不同。肥厚型心肌病患者的MMa/MMc活性比值（0.61±0.25）显著高于正常对照者（0.30±0.10；P<0.01）。4. 我们的结果表明，许多肥厚型心肌病患者中存在少量肌酸激酶MM的心肌组织同工酶（MMa）持续释放。