兔子宫颈原胶原酶激活剂被鉴定为兔基质金属蛋白酶3（基质溶解素）。
Identification of rabbit uterine cervical procollagenase activator as rabbit matrix metalloproteinase 3 (stromelysin).
作者信息
Ito A, Itoh Y, Sato T, Mori Y, Suzuki K, Nagase H
机构信息
Department of Biochemistry, Tokyo College of Pharmacy, Japan.
出版信息
Comp Biochem Physiol B. 1991;99(2):381-5. doi: 10.1016/0305-0491(91)90058-l.
PMID:1662594
Abstract
- We previously reported an endogenous activator of procollagenase from the culture medium of rabbit uterine cervical fibroblasts (Ishibashi et al. (1987) Biochem. J. 241, 527-534). 2. Similar activator was also purified and characterized from rabbit synovial fibroblasts (Vater et al. (1983) J. biol. Chem. 258, 9374-9382), but its mode of activation of procollagenase was reported to be different from that of purified activator from uterine cervical fibroblasts. 3. Here we report the comparative studies of the two activators of procollagenase and demonstrate that they are identified as matrix metalloproteinase 3 (stromelysin) by their immunological and functional criteria. The specific role of the activator in procollagenase activation is also described.
摘要
- 我们先前报道过从兔子宫颈成纤维细胞培养基中提取的前胶原酶内源性激活剂（石桥等人，《生物化学杂志》（1987年）第241卷，第527 - 534页）。2. 类似的激活剂也从兔滑膜成纤维细胞中得到纯化和鉴定（瓦特等人，《生物化学杂志》（1983年）第258卷，第9374 - 9382页），但据报道其激活前胶原酶的方式与从子宫颈成纤维细胞中纯化得到的激活剂不同。3. 在此我们报道了这两种前胶原酶激活剂的比较研究，并通过免疫学和功能标准证明它们被鉴定为基质金属蛋白酶3（基质溶素）。还描述了激活剂在前胶原酶激活中的具体作用。
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Identification of rabbit uterine cervical procollagenase activator as rabbit matrix metalloproteinase 3 (stromelysin).兔子宫颈原胶原酶激活剂被鉴定为兔基质金属蛋白酶3（基质溶解素）。
Comp Biochem Physiol B. 1991;99(2):381-5. doi: 10.1016/0305-0491(91)90058-l.
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Procollagenase activator produced by rabbit uterine cervical fibroblasts.兔子宫颈成纤维细胞产生的前胶原酶激活剂。
Biochem J. 1987 Jan 15;241(2):527-34. doi: 10.1042/bj2410527.
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