钯配合物催化炔烃分子内氢酰胺化反应合成内酰胺
Lactam synthesis via the intramolecular hydroamidation of alkynes catalyzed by palladium complexes.
作者信息
Patil Nitin T, Huo Zhibao, Bajracharya Gan B, Yamamoto Yoshinori
机构信息
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
出版信息
J Org Chem. 2006 Apr 28;71(9):3612-4. doi: 10.1021/jo060142x.
PMID:16626149
Abstract
The palladium complexes catalyzed intramolecular hydroamidation reaction of amidoalkynes gives the corresponding lactams in good to high yields. For example, in the presence of 10 mol % of Pd(PPh3)4 and 20 mol % of PhCOOH, the reaction of the amidoalkyne 3a in 1,4-dioxane at 100 degrees C proceeded smoothly to give the corresponding lactam 4a in 92% yield.
摘要
钯配合物催化的酰胺基炔烃分子内氢氨化反应能以良好至高收率得到相应的内酰胺。例如，在10 mol%的四（三苯基膦）钯和20 mol%的苯甲酸存在下，酰胺基炔烃3a在1,4 - 二氧六环中于100℃反应顺利进行，以92%的收率得到相应的内酰胺4a。
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