Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104, Freiburg i. Brsg., Germany.
Department of Chemistry, University of Texas at Austin, 105 E 24th St. Welch Hall, A5300, Austin, TX, 78712-1167, USA.
Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11312-11325. doi: 10.1002/anie.201704248. Epub 2017 Aug 10.
Diverse late transition metal catalysts convert terminal or internal alkynes into transient allylmetal species that display electrophilic or nucleophilic properties. Whereas classical methods for the generation of allylmetal species often form stoichiometric by-products, the recent use of alkynes as allylmetal precursors enables completely atom-efficient catalytic processes to be carried out, including enantioselective transformations.
各种晚期过渡金属催化剂将末端或内部炔烃转化为显示亲电性或亲核性的瞬态烯丙基金属物种。虽然经典的烯丙基金属物种生成方法通常会形成化学计量的副产物,但最近使用炔烃作为烯丙基金属前体可以实现完全原子经济的催化过程,包括对映选择性转化。