单取代、二取代和三取代α-无支链肼的简便合成。

Facile synthesis of mono-, di-, and trisubstituted alpha-unbranched hydrazines.

作者信息

Rasmussen Lars K

机构信息

The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

出版信息

J Org Chem. 2006 Apr 28;71(9):3627-9. doi: 10.1021/jo0525783.

DOI:10.1021/jo0525783

PMID:16626153

Abstract

Methods for the alkylation of di-tert-butyl hydrazine-1,2-dicarboxylate were investigated. It was found that under mild conditions mono- or di-substituted hydrazine derivatives were obtained in good to excellent yield. Furthermore, it was shown that one of the two Boc-groups of the disubstituted derivatives was selectively removed by heating, leading to precursors for trisubstituted hydrazines.

摘要

研究了二叔丁基肼-1,2-二羧酸酯的烷基化方法。发现在温和条件下可获得产率良好至优异的单取代或二取代肼衍生物。此外，结果表明，二取代衍生物的两个Boc基团之一通过加热被选择性除去，从而得到三取代肼的前体。