Berglund Ryan K, Lyden Sean P, Tsai Eve C, Lieberman Isador, Klein Eric A
Section of Urologic Oncology, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Eur Urol. 2006 Aug;50(2):372-4. doi: 10.1016/j.eururo.2006.01.060. Epub 2006 Mar 13.
Bony metastasis is a rare feature of metastatic nonseminomatous germ cell tumor. A 25 year-old man presented with back pain radiating down both legs, and a subsequent work-up demonstrated a right-sided testicular mass with bilateral retroperitoneal lymphadenopathy and tumor involvement of the L2 vertebra. Radical inguinal orchiectomy confirmed nonseminomatous germ cell tumor, and the patient underwent chemotherapy with a residual mass and vertebral involvement by MRI. Combined vertebral resection with spinal reconstruction and retroperitoneal lymph node dissection demonstrated residual fibrosis. While bony metastasis of nonseminomatous germ cell tumors is rare, resection with spinal reconstruction can be accomplished with acceptable morbidity.
骨转移是转移性非精原细胞瘤性生殖细胞肿瘤的一种罕见特征。一名25岁男性因背痛放射至双下肢就诊，随后的检查显示右侧睾丸肿块伴双侧腹膜后淋巴结肿大以及L2椎体受肿瘤侵犯。根治性腹股沟睾丸切除术确诊为非精原细胞瘤性生殖细胞肿瘤，患者接受化疗后MRI显示仍有残留肿块及椎体受累。联合椎体切除、脊柱重建及腹膜后淋巴结清扫显示有残留纤维化。虽然非精原细胞瘤性生殖细胞肿瘤的骨转移罕见，但通过脊柱重建进行切除可在可接受的发病率范围内完成。
