Veiga Sergio, Leonelli Emanuela, Beelke Manolo, Garcia-Segura Luis M, Melcangi Roberto C
Instituto Cajal, C.S.I.C., Avenida Dr. Arce 37, 28002 Madrid, Spain.
Neurosci Lett. 2006 Jul 10;402(1-2):150-3. doi: 10.1016/j.neulet.2006.03.058. Epub 2006 Apr 19.
The effect of the neuroactive steroids progesterone, dihydroprogesterone and tetrahydroprogesterone on myelin abnormalities induced by diabetes was studied in the sciatic nerve of adult male rats treated with streptozotocin. Streptozotocin increased blood glucose levels and decreased body weight gain, parameters not affected by steroids. Streptozotocin increased the number of fibers with myelin infoldings in the axoplasm, 8 months after the treatment. Chronic treatment for 1 month with progesterone and dihydroprogesterone resulted in a significant reduction in the number of fibers with myelin infoldings to control levels. Treatment with tetrahydroprogesterone did not significantly affect this myelin alteration. These results suggest that neuroactive steroids such as progesterone and dihydroprogesterone may represent therapeutic alternatives to counteract peripheral myelin alterations induced by diabetes.
在经链脲佐菌素处理的成年雄性大鼠的坐骨神经中，研究了神经活性甾体孕酮、二氢孕酮和四氢孕酮对糖尿病诱导的髓鞘异常的影响。链脲佐菌素可提高血糖水平并降低体重增加，甾体对此参数无影响。治疗8个月后，链脲佐菌素增加了轴质中具有髓鞘折叠的纤维数量。用孕酮和二氢孕酮进行1个月的慢性治疗，可使具有髓鞘折叠的纤维数量显著减少至对照水平。用四氢孕酮治疗对这种髓鞘改变没有显著影响。这些结果表明，孕酮和二氢孕酮等神经活性甾体可能是对抗糖尿病诱导的外周髓鞘改变的治疗选择。
