Hazzard W R, Bierman E L
Metabolism. 1975 Jul;24(7):817-28. doi: 10.1016/0026-0495(75)90128-6.
To assess the roles of endogenous and exogenous lipid in the production of the abnormal lipoprotein patterns characteristic of broad-beta desease (with a type IVIII lipoprotein pattern) and endogenous hypertriglyceridemia (with a type IV pattern), oral fat loads (50 g/M-2) were administered to six subjects with broad-beta disease and to eight with endogenous hypertriglyceridemia following at leat 72 hr of 0% fat, 85% carbohydrate isocaloric formula feeding. Total plasma and Sf greater than 400, 100-400, 60-100, 30-60, and 20-30 lipoprotein cholesterol, triglyceride, and phospholipid levels were measured at 0 hr, 6 hr (at or before the peak of alimentary lipemia), and 24 hr following the fat load. Following fat-free feeding the levels and composition of the endogenous Sf greater than 400 lipoproteins were similar in both disorders; whereas total Sf20-400, and most notably, Sf 30-60 and 20-30 levels were increased and enriched in cholesterol in the subjects with broad-beta disease.
为评估内源性和外源性脂质在产生宽β病（具有IV/III型脂蛋白模式）特征性异常脂蛋白模式以及内源性高甘油三酯血症（具有IV型模式）中的作用，在至少72小时的0%脂肪、85%碳水化合物等热量配方喂养后，对6名宽β病患者和8名内源性高甘油三酯血症患者给予口服脂肪负荷（50 g/M²）。在脂肪负荷后0小时、6小时（在食饵性脂血症峰值时或之前）和24小时测量总血浆以及Sf大于400、100 - 400、60 - 100、30 - 60和20 - 30的脂蛋白胆固醇、甘油三酯和磷脂水平。在无脂肪喂养后，两种疾病中内源性Sf大于400脂蛋白的水平和组成相似；而宽β病患者中总Sf20 - 400，最显著的是Sf 30 - 60和20 - 30水平升高且胆固醇含量增加。
