[评价针对爱泼斯坦-巴尔病毒衣壳和早期抗原的IgG和IgA型抗体在鼻咽癌诊断中的作用]
[Evaluation of IgG and IgA type antibodies to capsid and early antigens of the Epstein-Barr virus in the diagnosis of nasopharyngeal carcinoma].
作者信息
Mendoza J, Rojas A, de la Rosa M, Amador J M, Expósito J, Esquivias J
机构信息
Servicio de Microbiología, Hospital Regional Virgen de las Nieves, Granada.
出版信息
Med Clin (Barc). 1991 Nov 9;97(16):609-11.
BACKGROUND
The Epstein-Barr virus (EBV) is related with nasopharyngeal carcinoma (NPC) in that, in this neoplasm, high levels of antibodies are found vs different EBV antigens.
METHODS
The determinations of IgG and IgA type antibodies were evaluated vs capsid antigens (VCA) and early antigen (EA) of the EBV by indirect immunofluorescence in 14 patients diagnosed with NPC, in 12 patients with other tumors of the head and neck and in 61 blood donors.
RESULTS
The detection of IgA type antibodies with a sensitivity and specificity of 100% and 92% for the VCA antigen and of 86% and 100% for the EA antigen are the most useful tests in the early diagnosis of nasopharyngeal carcinoma. The determination of IgG type antibodies were of a more limited usefulness with sensitivities and specificities of 86% and 67% for IgG anti-VCA and 100% and 83% of IgG anti-EA.
CONCLUSIONS
The detection of antibodies vs VCA and EA antigens is useful in the differential diagnosis of NPC with other tumors of the head and neck.
背景
爱泼斯坦-巴尔病毒（EBV）与鼻咽癌（NPC）相关，因为在这种肿瘤中发现针对不同EBV抗原的高水平抗体。
方法
通过间接免疫荧光法，对14例确诊为鼻咽癌的患者、12例患有其他头颈部肿瘤的患者和61名献血者检测针对EBV衣壳抗原（VCA）和早期抗原（EA）的IgG和IgA型抗体。
结果
检测到的IgA型抗体对VCA抗原的敏感性和特异性分别为100%和92%，对EA抗原的敏感性和特异性分别为86%和100%，是鼻咽癌早期诊断中最有用的检测方法。IgG型抗体的检测有用性更有限，IgG抗VCA的敏感性和特异性分别为86%和67%，IgG抗EA的敏感性和特异性分别为100%和83%。
结论
检测针对VCA和EA抗原的抗体有助于鼻咽癌与其他头颈部肿瘤的鉴别诊断。
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