Falagas Matthew E, Kasiakou Sofia K, Rafailidis Petros I, Zouglakis George, Morfou Panayiota
Alfa Institute of Biomedical Sciences (AIBS) Athens, Greece.
J Antimicrob Chemother. 2006 Jun;57(6):1251-4. doi: 10.1093/jac/dkl130. Epub 2006 Apr 20.
To evaluate the effect of inappropriate empirical antimicrobial treatment on the mortality of patients with Acinetobacter baumannii bacteraemia.
Retrospective cohort study of patients with A. baumannii bacteraemia hospitalized at the Henry Dunant hospital from January 2002 to December 2004.
Among 40 patients with A. baumannii bacteraemia, 22 (55%) and 18 (45%) received inappropriate and appropriate antibiotic therapy, respectively, during the 3 day period after obtaining the blood culture(s) from which the pathogen was isolated. Failure to cure the infection was more common in the first group [16/22 patients (72.7%) versus 5/18 (27.8%), P = 0.005]. Although without statistical significance, probably due to the small number of studied patients, considerably increased mortality was noted in the first group compared with the second group [13/22 patients (59.1%) versus 6/18 (33.3%), P = 0.10].
A. baumannii bacteraemia was associated with worse outcome regarding the cure of infection in patients who received inappropriate empirical antimicrobial treatment compared with those who received appropriate treatment.
评估不恰当的经验性抗菌治疗对鲍曼不动杆菌血症患者死亡率的影响。
对2002年1月至2004年12月在亨利·杜南医院住院的鲍曼不动杆菌血症患者进行回顾性队列研究。
在40例鲍曼不动杆菌血症患者中，分别有22例（55%）和18例（45%）在从血培养中分离出病原体后的3天内接受了不恰当和恰当的抗生素治疗。感染未治愈在第一组中更为常见[22例患者中有16例（72.7%），而18例中有5例（27.8%），P = 0.005]。虽然无统计学意义，可能是由于研究患者数量较少，但与第二组相比，第一组的死亡率显著增加[22例患者中有13例（59.1%），而18例中有6例（33.3%），P = 0.10]。
与接受恰当治疗的患者相比，接受不恰当经验性抗菌治疗的鲍曼不动杆菌血症患者在感染治愈方面的结局更差。
