Kovacs Kalman, Bell David, Gardiner Geoffrey W, Honey R John, Goguen Jeannette, Rotondo Fabio
Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Endocr Pathol. 2005 Winter;16(4):363-9. doi: 10.1385/ep:16:4:363.
Using various immunohistochemical markers, the objective of our study was to assess whether correlation exists between growth potential of paraganglioma (pheochromocytoma) cells and formation of metastasis. The patient was a 28-yr-old man who presented with intermittent episodes of gross hematuria due to a mass in the urinary bladder. He had no constitutional symptoms to suggest paraganglioma. Histologic, immunohistochemical, and electron microscopic investigation of the surgically removed tissue proved that the tumor was a malignant paraganglioma with metastases in the regional lymph nodes. The immunohistochemical tests were not supportive of high cell proliferation index, indicating that metastases can develop in the absence of rapid multiplication of the tumor cells. Abnormalities in vascular architecture and marked expression of VEGF in the tumor cells may be regarded as prognostic signs to predict the formation of metastases.
我们使用各种免疫组织化学标志物进行研究，目的是评估副神经节瘤（嗜铬细胞瘤）细胞的生长潜能与转移形成之间是否存在相关性。该患者为一名28岁男性，因膀胱肿物出现间歇性肉眼血尿。他没有提示副神经节瘤的全身症状。对手术切除组织进行的组织学、免疫组织化学和电子显微镜检查证明，该肿瘤是恶性副神经节瘤，伴有区域淋巴结转移。免疫组织化学检测不支持高细胞增殖指数，这表明在肿瘤细胞没有快速增殖的情况下也可能发生转移。肿瘤血管结构异常以及肿瘤细胞中VEGF的显著表达可被视为预测转移形成的预后指标。
