Gong Kan, Zhang Ning, Zhang Zheng, Na Yanqun
Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, Beijing, PR China.
Cancer Biol Ther. 2006 Jun;5(6):582-5. doi: 10.4161/cbt.5.6.2709. Epub 2006 Jun 15.
Clear cell renal cell carcinoma (CCRCC) is the most common renal carcinoma and it is often associated with von Hippel-Lindau disease (VHL) gene mutations. CCRCCs with VHL mutations demonstrate hypoxia-inducible factor (HIF) overexpression as well as increased expression of vascular endothelial growth factor (VEGF). Recently, the erythropoietin (Epo) has been found to be upregulated in renal and other tumors associated with VHL disease. Furthermore, Epo and Epo receptor (EpoR) coexpression has also been reported in these tumors. The results provided strong evidence that an autocrine loop is involved in tumorigenesis in VHL disease. We investigated whether Epo and EpoR coexpression also occurs in sporadic CCRCC. Fifty-four sporadic CCRCCs were analyzed. VHL gene mutations were detected in 30 out of 54 tumors. Coexpression of Epo and EpoR was detected in 50 out of 54 tumors regardless of their VHL mutation status. The results suggest that coexpression of Epo and EpoR plays an important role in tumorigenesis of sporadic CCRCC.
透明细胞肾细胞癌（CCRCC）是最常见的肾癌，它常与冯·希佩尔-林道病（VHL）基因突变相关。具有VHL突变的CCRCC表现出缺氧诱导因子（HIF）过表达以及血管内皮生长因子（VEGF）表达增加。最近，已发现促红细胞生成素（Epo）在与VHL病相关的肾脏及其他肿瘤中上调。此外，在这些肿瘤中也报道了Epo与促红细胞生成素受体（EpoR）的共表达。这些结果提供了有力证据，表明自分泌环参与了VHL病的肿瘤发生。我们研究了Epo与EpoR的共表达是否也发生在散发性CCRCC中。分析了54例散发性CCRCC。在54例肿瘤中的30例检测到VHL基因突变。无论VHL突变状态如何，在54例肿瘤中的50例检测到Epo与EpoR的共表达。结果表明，Epo与EpoR的共表达在散发性CCRCC的肿瘤发生中起重要作用。
