Cutrer F Michael
Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
Semin Neurol. 2006 Apr;26(2):171-80. doi: 10.1055/s-2006-939917.
The cause and pathophysiology of migraine are not well understood. Over the years research into migraine pathophysiology has focused on the physiology and pharmacology of the headache, the changes in cerebral cortex associated with the symptoms of the aura, and more recently the genetics underlying the migraine syndromes. In this discussion, the neuroanatomical structures activated during migraine attacks, the traditional theories of migraine that serve as the foundation for current research, and the essential findings from current migraine pathophysiological research will be reviewed. Investigations in migraine can be divided into those related to the brain events initiating a migraine attack, those examining the mechanisms of activation and transmission within trigeminal afferent neurons, and those focused on the effect of and the modulation of nociception trigeminal input within the central nervous system.
偏头痛的病因和病理生理学尚未完全明确。多年来，偏头痛病理生理学的研究主要集中在头痛的生理学和药理学、与先兆症状相关的大脑皮层变化，以及最近偏头痛综合征的遗传学基础。在本次讨论中，将回顾偏头痛发作期间激活的神经解剖结构、作为当前研究基础的传统偏头痛理论，以及当前偏头痛病理生理学研究的重要发现。偏头痛的研究可分为与引发偏头痛发作的大脑事件相关的研究、研究三叉神经传入神经元内激活和传递机制的研究，以及关注中枢神经系统内伤害性三叉神经输入的影响和调节的研究。
