Duzovali Oznur, Chan Ka Wah
Department of Pediatrics, Division of Pediatric Oncology, Mersin University, Zeytinlibahce, Mersin, Turkey.
Pediatr Blood Cancer. 2007 Feb;48(2):218-21. doi: 10.1002/pbc.20870.
Extracorporeal photochemotherapy (ECP) is an alternative treatment approach in the management of chronic graft-versus-host disease (cGVHD). However, few reports have investigated the optimal treatment schedule of ECP. We treated seven pediatric patients with steroid-resistant or -dependent cGVHD with ECP. Using the Therakos UVAR XTS system, ECP was begun three (three patients) or five (four patients) times a week initially. Complete and partial responses were obtained in three patients. Three of seven patients died of GVHD-related complications. In this group initial intensive ECP did not improve the rate of response. However, this schedule appeared well tolerated.
体外光化学疗法（ECP）是治疗慢性移植物抗宿主病（cGVHD）的一种替代治疗方法。然而，很少有报告研究ECP的最佳治疗方案。我们用ECP治疗了7例对类固醇耐药或依赖的小儿cGVHD患者。使用Therakos UVAR XTS系统，最初每周进行3次（3例患者）或5次（4例患者）ECP治疗。3例患者获得了完全缓解和部分缓解。7例患者中有3例死于GVHD相关并发症。在这组患者中，最初的强化ECP治疗并未提高缓解率。然而，这种治疗方案似乎耐受性良好。
