替马沙星对包括耐甲氧西林金黄色葡萄球菌在内的革兰氏阳性球菌的体外活性。

In vitro activity of temafloxacin against gram-positive cocci including methicillin-resistant Staphylococcus aureus.

作者信息

Fuchs P C

机构信息

Department of Pathology, St. Vincent Hospital and Medical Center, Portland, Oregon 97225.

出版信息

Am J Med. 1991 Dec 30;91(6A):15S-18S. doi: 10.1016/0002-9343(91)90303-f.

DOI:10.1016/0002-9343(91)90303-f

PMID:1662886

Abstract

Published reports on the in vitro activity of temafloxacin indicate its activity against gram-positive cocci is equal to or slightly greater than that of ciprofloxacin, and generally twofold greater than that of ofloxacin. The few ciprofloxacin-resistant Staphylococcus aureus strains reported were also resistant to temafloxacin. Because temafloxacin achieves higher plasma and tissue levels than ciprofloxacin, greater differences between minimal inhibitory concentrations and tissue levels occur with temafloxacin than with ciprofloxacin, which may provide temafloxacin with greater therapeutic efficiency against gram-positive coccal infections.

摘要

已发表的关于替马沙星体外活性的报告表明，其对革兰氏阳性球菌的活性等同于或略高于环丙沙星，且通常比对氧氟沙星高两倍。报告的少数耐环丙沙星金黄色葡萄球菌菌株对替马沙星也耐药。由于替马沙星在血浆和组织中达到的水平高于环丙沙星，与环丙沙星相比，替马沙星的最低抑菌浓度与组织水平之间的差异更大，这可能使替马沙星对革兰氏阳性球菌感染具有更高的治疗效果。