Morgan J E
Department of Paediatrics, Division of Medicine, Imperial College London, The Dubowitz Neuromuscular Unit, Hammersmith Hospital.
Acta Myol. 2005 Dec;24(3):181-3.
Stem cells, capable of giving rise to both differentiated skeletal muscle and to more stem cells, would be ideal for treating chronic myopathies such as Duchenne Muscular Dystrophy. However, although satellite cells have been shown to be functional muscle stem cells in animal models, other muscle or non-muscle stem cells are far less capable of contributing to skeletal muscle regeneration. This review discusses recent work on stem cell contribution to skeletal muscle regeneration and highlights the problems to be overcome before stem cell treatment of muscle diseases may become a possibility.
能够分化为骨骼肌和产生更多干细胞的干细胞，对于治疗诸如杜氏肌营养不良症等慢性肌病来说将是理想的选择。然而，尽管在动物模型中卫星细胞已被证明是功能性肌肉干细胞，但其他肌肉或非肌肉干细胞对骨骼肌再生的贡献要小得多。这篇综述讨论了干细胞对骨骼肌再生贡献的最新研究，并强调了在干细胞治疗肌肉疾病成为可能之前需要克服的问题。
