The Dubowitz Neuromuscular Centre, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom.
Neuromuscul Disord. 2011 Jan;21(1):4-12. doi: 10.1016/j.nmd.2010.10.004. Epub 2010 Nov 4.
The muscular dystrophies are inherited disorders characterised by progressive muscle wasting and weakness. Stem cell therapy is considered to be one of the most promising strategies for treating muscular dystrophies. In this review, we first examine the evidence that a stem cell could be used to treat muscular dystrophies, and then discuss the criteria that an ideal stem cell should meet. We also highlight the importance of standard operation procedures to be followed for ensuring the consistent and reproducible efficacy of a particular stem cell. While at the moment the scientific community is looking for an ideal stem cell to treat muscular dystrophies, it is clear that in order for this field to benefit from therapeutic stem cell applications, additional careful investigations are required.
肌肉萎缩症是一种遗传性疾病，其特征是肌肉逐渐萎缩和无力。干细胞疗法被认为是治疗肌肉萎缩症最有前途的策略之一。在这篇综述中，我们首先检查了使用干细胞治疗肌肉萎缩症的证据，然后讨论了理想的干细胞应满足的标准。我们还强调了为确保特定干细胞的一致和可重复的疗效而应遵循的标准操作程序的重要性。虽然目前科学界正在寻找一种理想的干细胞来治疗肌肉萎缩症，但显然，为了使该领域受益于治疗性干细胞应用，还需要进行更多的仔细研究。
