[侵袭性肺炎球菌感染患儿肺炎链球菌的血清型分布及青霉素结合蛋白基因]
[Serotype distribution and penicillin-binding protein genes of Streptococcus pneumoniae in children with invasive pneumococcal infection].
作者信息
Sakata Hiroshi, Ubukata Kimiko, Chiba Naoko
机构信息
Department of Pediatrics, Asahikawa Kosei Hospital.
出版信息
Kansenshogaku Zasshi. 2006 Mar;80(2):91-6. doi: 10.11150/kansenshogakuzasshi1970.80.91.
Between August 1998 and July 2005, we studied the serotypes and mutation of penicillin-binding protein (PBP) genes of 46 strains of Streptococcus pneumoniae isolated from children with invasive pneumococcal infection in Hokkaido. The clinical diagnosis was pneumonia in 16 cases, occult bacteremia in 15, meningitis in 8, upper respiratory infection in 6, and arthritis in 1. Patients ranged in age from 2 months to 9 years old. Prevalent serotypes were 6B (39.1%), 23F (17.4%) 6A (8.7%), and 19F (8.7%). The serotype coverage rate by the 7-valent pneumococcal vaccine was greater than 70% in children. Mutation of 3 genes (Penicillin-binding S. pneumoniae, PRSP) was detected in 18 isolates, mutation of 10 genes (pbp1a and pbp2x, or pbp2x and pbp2b) in 2, and of pbp2x alone in 15. PRSP was found in serotypes 6A, 6B, and 23F, and the rate of PRSP in 6A, 6B, and 23F was 75.0%, 62.5%, and 55.6%, respectively.
1998年8月至2005年7月期间，我们对从北海道侵袭性肺炎球菌感染患儿中分离出的46株肺炎链球菌的血清型和青霉素结合蛋白（PBP）基因的突变情况进行了研究。临床诊断为肺炎16例，隐匿性菌血症15例，脑膜炎8例，上呼吸道感染6例，关节炎1例。患者年龄从2个月至9岁不等。流行血清型为6B（39.1%）、23F（17.4%）、6A（8.7%）和19F（8.7%）。7价肺炎球菌疫苗对儿童的血清型覆盖率大于70%。在18株分离株中检测到3个基因（肺炎链球菌青霉素结合蛋白，PRSP）的突变，2株中检测到10个基因（pbp1a和pbp2x，或pbp2x和pbp2b）的突变，15株中仅检测到pbp2x的突变。在血清型6A、6B和23F中发现了PRSP，6A、6B和23F中PRSP的发生率分别为75.0%、62.5%和55.6%。
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