一名在妊娠中期发生暴发性肝衰竭的女性成功进行肝移植并分娩。
Successful liver transplantation and delivery in a woman with fulminant hepatic failure occurring during the second trimester of pregnancy.
作者信息
Jarufe Nicolás, Soza Alejandro, Pérez-Ayuso Rosa María, Poblete José Andrés, González Robinson, Guajardo Matías, Hernandez Verónica, Riquelme Arnoldo, Arrese Marco, Martínez Jorge
机构信息
Unidad de Higado y Departament de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile.
出版信息
Liver Int. 2006 May;26(4):494-7. doi: 10.1111/j.1478-3231.2006.01246.x.
BACKGROUND
Severe liver dysfunction occurring during pregnancy is an unusual but dramatic event that poses special technical and ethical issues because it involves two lives.
METHODS AND RESULTS
We report the case of a 35-year-old woman with cryptogenic fulminant hepatic failure who underwent successful orthotopic liver transplantation at 22 weeks of pregnancy. After a relatively uneventful post-operative course she delivered a normal offspring at the 27th week of gestation. There were no obstetrical complications and neonatal outcome was excellent. After a year of follow-up, the patient is doing well,and the newborn has exhibited normal psychomotor and weight/height development.
CONCLUSION
This case illustrates the challenge of treating fulminant hepatic failure during pregnancy and demonstrates that liver transplantation is a feasible therapeutic option for treatment of patients with this condition, allowing successful completion of pregnancy.
背景
孕期发生的严重肝功能障碍是一种罕见但严重的事件，由于涉及两条生命，会带来特殊的技术和伦理问题。
方法与结果
我们报告一例35岁患有隐源性暴发性肝衰竭的女性病例，该患者在妊娠22周时接受了成功的原位肝移植。术后过程相对平稳，她在妊娠第27周时分娩出一个正常的后代。没有产科并发症，新生儿结局良好。经过一年的随访，患者情况良好，新生儿的精神运动以及体重/身高发育均正常。
结论
该病例说明了孕期治疗暴发性肝衰竭的挑战，并表明肝移植是治疗这种疾病患者的一种可行治疗选择，能够使妊娠成功完成。
Zotero 插件