QT离散度随年龄增长而增加。

QT dispersion increases with aging.

作者信息

Yavuz Bunyamin, Deveci Onur Sinan, Yavuz Burcu Balam, Halil Meltem, Aytemir Kudret, Cankurtaran Mustafa, Kabakci Giray, Kaya Baris, Ariogul Servet, Oto Ali

机构信息

Department of Cardiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

出版信息

Ann Noninvasive Electrocardiol. 2006 Apr;11(2):127-31. doi: 10.1111/j.1542-474X.2006.00093.x.

DOI:10.1111/j.1542-474X.2006.00093.x

PMID:16630086

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7313311/

Abstract

BACKGROUND

Age-related changes in cardiovascular system are well-known. Arrhythmias in elderly patients constitute most of the urgencies, consultations, or hospitalizations. QT dispersion (QTd) is a simple noninvasive arrhythmogenic marker to demonstrate the electrical instability of the heart. The aim of this study was to investigate how QTd changes with increasing age by calculating the QTd in the elderly and younger subjects.

METHODS

One hundred and forty-six consecutive subjects (62 males and 84 females; age range: 18-82 years) were enrolled in the study. Sixty-seven of the subjects were 65 years and over (mean age, 70 +/- 4), 79 were younger than 65 (mean age, 37 +/- 11). A 12-lead ECG was recorded. The longest and the shortest QT intervals were measured manually on these ECG recordings. QTd was calculated from the formula, QTd = QTmax - QTmin.

RESULTS

Demographic features were similar between the two groups. QTd of the elderly group was found to be significantly higher than the younger group (35.6 +/- 15.6 in elderly, 24.2 +/- 12.4 in younger group, P < 0.001). A positive relationship was found between QTd and age (r = 0.415, P < 0.001). QTd was greater in female than in male (31.9 +/- 16.7 ms vs 26.0 +/- 11.3 ms, respectively, P = 0.018).

CONCLUSIONS

Our study shows that QTd increases with advancing age. We think that long-term follow-up of these patients would be useful to show if there is any relationship between the clinical outcomes and the increase in QTd.

摘要

背景

心血管系统的年龄相关性变化是众所周知的。老年患者的心律失常构成了大多数急诊、会诊或住院情况。QT离散度（QTd）是一种简单的无创致心律失常标志物，用于显示心脏的电不稳定性。本研究的目的是通过计算老年和年轻受试者的QTd来研究QTd如何随年龄增长而变化。

方法

连续纳入146名受试者（62名男性和84名女性；年龄范围：18 - 82岁）。其中67名受试者年龄在65岁及以上（平均年龄，70±4），79名年龄小于65岁（平均年龄，37±11）。记录12导联心电图。在这些心电图记录上手动测量最长和最短QT间期。QTd根据公式QTd = QTmax - QTmin计算得出。

结果

两组的人口统计学特征相似。发现老年组的QTd显著高于年轻组（老年组为35.6±15.6，年轻组为24.2±12.4，P < 0.001）。发现QTd与年龄呈正相关（r = 0.415，P < 0.001）。女性的QTd大于男性（分别为31.9±16.7 ms和26.0±11.3 ms，P = 0.018）。