Jang Ki-Seok, Paik Seung Sam, Chung Heekyoung, Oh Young-Ha, Kong Gu
Department of Pathology, College of Medicine, Hanyang University, 17 Haengdang-Dong, Seongdong-Gu, Seoul, 133-791, Republic of Korea.
Cancer Sci. 2006 May;97(5):374-9. doi: 10.1111/j.1349-7006.2006.00186.x.
Metastasis associated antigen 1 (MTA1) is a recently identified candidate metastasis-associated gene that plays an important role in tumorigenesis and tumor aggressiveness, especially tumor invasiveness and metastasis. We analyzed the relationship between MTA1 expression and variable clinicopathological features and characterized its role in tumor angiogenesis in human breast cancers. Two hundred and sixty-three breast cancer cases that successfully underwent surgery at Hanyang University Hospital (Seoul, Korea) between January 1989 and December 1997 were enrolled. MTA1 expression was observed by immunohistochemical staining and correlated with intratumoral microvessel density (MVD) and other clinicopathological parameters. MTA1 overexpression correlated significantly with higher tumor grade (grades 1 and 2 vs grade 3, P = 0.009). However, MTA1 expression did not correlate with tumor stage, status of estrogen and progesterone receptors, or axillary lymph node metastasis. Interestingly, MTA1 expression was found to correlate significantly with tumor MVD (P = 0.002). Survival analysis did not show a significant difference between MTA1 overexpression and poorer survival. In conclusion, MTA1 overexpression was found to be closely associated with higher tumor grade and increased tumor angiogenesis. These findings suggest MTA1 as a predictor of aggressive phenotype and a possible target molecule for anti-angiogenic drugs in breast cancer treatment.
转移相关抗原1（MTA1）是最近鉴定出的一种与转移相关的候选基因，在肿瘤发生和肿瘤侵袭性，尤其是肿瘤侵袭和转移过程中发挥重要作用。我们分析了MTA1表达与多种临床病理特征之间的关系，并明确了其在人类乳腺癌肿瘤血管生成中的作用。纳入了1989年1月至1997年12月期间在韩国首尔汉阳大学医院成功接受手术的263例乳腺癌病例。通过免疫组织化学染色观察MTA1表达，并将其与肿瘤内微血管密度（MVD）及其他临床病理参数进行关联分析。MTA1过表达与较高的肿瘤分级显著相关（1级和2级与3级相比，P = 0.009）。然而，MTA1表达与肿瘤分期、雌激素和孕激素受体状态或腋窝淋巴结转移无关。有趣的是，发现MTA1表达与肿瘤MVD显著相关（P = 0.002）。生存分析显示MTA1过表达与较差的生存率之间无显著差异。总之，发现MTA1过表达与较高的肿瘤分级及肿瘤血管生成增加密切相关。这些发现表明MTA1可作为侵袭性表型的预测指标以及乳腺癌治疗中抗血管生成药物的潜在靶分子。
