Labbé J-C, Roy R
Institut de recherche en immunologie et en cancérologie, Universite de Montreal, Montreal, Quebec, Canada.
Clin Genet. 2006 Apr;69(4):306-14. doi: 10.1111/j.1399-0004.2006.00587.x.
The use of Caenorhabditis elegans as a model system for understanding animal development and human disease has long been recognized as an efficient tool of discovery. Recent developments, particularly in our understanding of RNA-mediated interference and its ability to modify gene activity, have facilitated the use of C. elegans in determining gene function via high-throughput analysis. These new strategies have provided a framework that allows investigators to analyse gene function globally at the genomic level and will likely become a prototypic model for biological analysis in the post-genome era.
长期以来，秀丽隐杆线虫作为一种用于理解动物发育和人类疾病的模式系统，一直被认为是一种高效的发现工具。最近的进展，特别是在我们对RNA介导的干扰及其改变基因活性能力的理解方面，促进了秀丽隐杆线虫在通过高通量分析确定基因功能中的应用。这些新策略提供了一个框架，使研究人员能够在基因组水平上全面分析基因功能，并且很可能会成为后基因组时代生物学分析的原型模型。
