Schrecengost John Edwin, Tabbara Sana, Patterson James, Wick Mark R
Division of Surgical Pathology, University of Virginia Medical Center, Charlottesville, VA 22908-0214, USA.
J Cutan Pathol. 2006 Apr;33(4):327-30. doi: 10.1111/j.0303-6987.2006.00414.x.
A 3-month-old infant girl presented with a polypoid lesion in the perianal region. No changes in this lesion had been noted since birth. Microscopic examination of the excised specimen showed a mixture of mesenchymal elements, dominated by haphazard thin fascicles of skeletal muscle. Collagen and vascular changes were also apparent. Immunohistochemistry showed positive staining for muscle-specific actin and desmin in the fascicular components of the lesion, and smooth muscle actin, desmin, and h-caldesmon positivity in a haphazard collection of muscle fibers in the deep dermis and anal submucosa. Numerous Verhoeff-van Gieson positive elastic fibers were also noted. Hamartomas containing skeletal muscle have rarely been reported outside of the head and neck region. They must be distinguished from a variety of other tumors, including juvenile rhabdomyoma, benign Triton tumor, and rhabdomyosarcoma.
一名3个月大的女婴肛周区域出现息肉样病变。自出生以来，该病变无变化。对切除标本进行显微镜检查显示为间充质成分的混合，以随意排列的薄骨骼肌束为主。胶原和血管变化也很明显。免疫组织化学显示病变的束状成分中肌特异性肌动蛋白和结蛋白呈阳性染色，在真皮深层和肛门黏膜下层随意排列的肌纤维中，平滑肌肌动蛋白、结蛋白和h-钙调蛋白呈阳性。还发现大量Verhoeff-van Gieson阳性弹性纤维。头颈部区域以外很少有含骨骼肌的错构瘤报道。它们必须与多种其他肿瘤相鉴别，包括幼年横纹肌瘤、良性蝾螈瘤和横纹肌肉瘤。
