Wandroo F, Stableforth P, Hasan Y
Department of Haematology, Sandwell and West Birmingham Hospital, Lyndon Road, West Bromwich, West Midlands B714HJ, UK.
Clin Lab Haematol. 2006 Apr;28(2):130-3. doi: 10.1111/j.1365-2257.2006.00737.x.
Cerebral aspergillosis is associated with very high mortality in immunocompromised hosts. Conventional antifungal agents like amphotericin-B and itraconazole are almost ineffective in cerebral aspergillosis. Newer azoles have been shown to penetrate the blood, cerebrospinal fluid barrier and achieve effective fungicidal concentrations. These newer azoles may change the outlook of this fatal condition. We report here a patient with cerebral aspergillosis who was successfully treated with voriconazole.
脑曲霉病在免疫功能低下的宿主中死亡率极高。传统抗真菌药物如两性霉素B和伊曲康唑对脑曲霉病几乎无效。新型唑类药物已被证明可穿透血脑屏障并达到有效的杀菌浓度。这些新型唑类药物可能会改变这种致命疾病的预后。我们在此报告一例脑曲霉病患者，该患者接受伏立康唑治疗后成功康复。
