对巴西分离出的携带与vanA质粒相关的Tn1546样元件的肠球菌的克隆性评估。
Evaluation of clonality in enterococci isolated in Brazil carrying Tn1546-like elements associated with vanA plasmids.
作者信息
Palazzo Izabel Cristina V, Camargo Ilana Lopes B C, Zanella Rosemeire C, Darini Ana Lúcia Costa
机构信息
Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Via do Café s/n, 14040903, Ribeirão Preto, SP, Brasil.
出版信息
FEMS Microbiol Lett. 2006 May;258(1):29-36. doi: 10.1111/j.1574-6968.2005.00181.x.
Fifty-one vancomycin-resistant enterococci samples isolated from different geographic regions in Brazil were studied. All the isolates harboured the vanA gene as demonstrated by PCR analysis, and in a majority of strains the gene was associated with a transferable plasmid of 70 kb. A single variant of the prototype Tn1546 associated with common transferable vanA-containing plasmids has spread among the enterococcal strains circulating in Brazil. The VanA element integrity in these enterococci strains and the different pulsed-field gel electrophoresis patterns suggest horizontal transmission of the vancomycin resistance transposon in Brazilian strains.
对从巴西不同地理区域分离出的51株耐万古霉素肠球菌样本进行了研究。PCR分析表明，所有分离株均携带vanA基因，并且在大多数菌株中，该基因与一个70 kb的可转移质粒相关。与常见的含vanA可转移质粒相关的原型Tn1546的单一变体已在巴西流行的肠球菌菌株中传播。这些肠球菌菌株中的VanA元件完整性以及不同的脉冲场凝胶电泳图谱表明，巴西菌株中万古霉素抗性转座子存在水平传播。
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