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Recognition of pore-forming colicin Y by its cognate immunity protein.

作者信息

Smajs David, Matejková Petra, Weinstock George M

机构信息

Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

出版信息

FEMS Microbiol Lett. 2006 May;258(1):108-13. doi: 10.1111/j.1574-6968.2006.00201.x.

DOI:10.1111/j.1574-6968.2006.00201.x
PMID:16630264
Abstract

Construction of hybrid immunity genes between colicin U (cui) and Y (cyi) immunity genes and site-directed mutagenesis of cyi were used to identify amino-acid residues of the colicin Y immunity protein (Cyi) involved in recognition of colicin Y. These amino-acid residues were localized close to the cytoplasmic site of the Cyi transmembrane helices T3 (S104, S107, F110, A112) and T4 (A159). Mutations in cui, which converted Cui sequence to Cyi sequence in positions 104, 107, 110, 112 and 159, resulted in an immunity gene that also conferred (besides immunity to colicin U) a high degree of immunity to colicin Y.

摘要

相似文献

1
Recognition of pore-forming colicin Y by its cognate immunity protein.
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2
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