Toshima Kazunobu
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan.
Carbohydr Res. 2006 Jul 24;341(10):1282-97. doi: 10.1016/j.carres.2006.03.012. Epub 2006 Apr 21.
In this short review article, several glycosylation methods that were developed in our laboratories, including stereocontrolled glycosylation using 2,6-anhydro-2,6-dideoxy-2,6-dithio sugars for obtaining 2,6-dideoxy glycosides, C-glycosylation employing unprotected sugars, environmentally benign glycosylation utilizing heterogeneous solid acids and ionic liquids, are recounted. In addition, representative and significant applications of these methods to the synthesis of complex natural products are described.
在这篇简短的综述文章中，我们讲述了在实验室中开发的几种糖基化方法，包括使用2,6-脱水-2,6-二脱氧-2,6-二硫代糖进行立体控制糖基化以获得2,6-二脱氧糖苷，使用未保护的糖进行C-糖基化，利用多相固体酸和离子液体进行环境友好型糖基化。此外，还描述了这些方法在复杂天然产物合成中的典型且重要的应用。
