限食的强制失同步大鼠的运动活动节律

Motor activity rhythms of forced desynchronized rats subjected to restricted feeding.

作者信息

Anglès-Pujolràs M, Chiesa J J, Díez-Noguera A, Cambras T

机构信息

Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Av Joan XXIII s/n, 08028 Barcelona, Spain.

出版信息

Physiol Behav. 2006 Jun 15;88(1-2):30-8. doi: 10.1016/j.physbeh.2006.03.004. Epub 2006 Apr 21.

DOI:10.1016/j.physbeh.2006.03.004

PMID:16630636

Abstract

Although light is the strongest zeitgeber for the circadian pacemaker, other stimuli can also produce entrainment. In the rat, periodic restricted feeding (RF) is a weak stimulus that may act as a zeitgeber. We tested the effect of RF on the motor activity rhythms of rats subjected to forced dissociation. In this situation two components, supposed to be related with the ventrolateral and dorsomedial areas of the suprachiasmatic nucleus, are detected in their motor activity. One component is entrained to the external light-dark cycle (Light Dependent Component, LDC) and thus has the same period, while the other has a period longer than 24 h (Non-Light Dependent Component, NLDC). This experiment examined whether RF can act on one or both of these two rhythms. Rats were maintained under the light-dark cycles of 22 h (T22) or 23 h (T23) for 44 days with food available for four hours per day. Afterwards the rats received food ad libitum, to test the effect of the previous RF condition. Results show that RF modifies the manifestation of the two initial rhythms, being this effect stronger under T23 than under T22. However RF does not affect the NLDC period. The results reveal that the animal can manifest simultaneously several rhythmic patterns.

摘要

尽管光是昼夜节律起搏器最强的授时因子，但其他刺激也能产生同步化。在大鼠中，周期性限食（RF）是一种可能作为授时因子的弱刺激。我们测试了RF对强制分离的大鼠运动活动节律的影响。在这种情况下，在其运动活动中检测到两个成分，推测与视交叉上核的腹外侧和背内侧区域有关。一个成分被同步到外部明暗周期（光依赖成分，LDC），因此具有相同的周期，而另一个成分的周期长于24小时（非光依赖成分，NLDC）。本实验研究了RF是否能作用于这两种节律中的一种或两种。大鼠在22小时（T22）或23小时（T23）的明暗周期下维持44天，每天有4小时可获取食物。之后，大鼠自由进食，以测试先前RF条件的影响。结果表明，RF改变了两种初始节律的表现，这种影响在T23条件下比在T22条件下更强。然而，RF不影响NLDC的周期。结果表明，动物可以同时表现出几种节律模式。