Rossi Derrick J, Weissman Irving L
Department of Pathology, Stanford University School of Medicine, Beckman Center B259, 279 Campus Drive, Stanford, CA 94305, USA.
Cell. 2006 Apr 21;125(2):229-31. doi: 10.1016/j.cell.2006.04.006.
Self-renewal pathways crucial for maintaining stem cells are deregulated in cancer, raising the spectre that cancer therapies targeting such pathways might also ablate normal stem cells. As Yilmaz et al. (2006) report in a recent Nature paper, this may not be the case for the tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem cells and the formation of leukemia cells through different mechanisms.
对于维持干细胞至关重要的自我更新途径在癌症中失调，这引发了一种担忧，即针对此类途径的癌症疗法可能也会消除正常干细胞。正如伊尔马兹等人在最近发表于《自然》杂志的一篇论文中所报道的，肿瘤抑制蛋白Pten可能并非如此，它通过不同机制驱动正常造血干细胞的自我更新以及白血病细胞的形成。
