Timmins Joanna, McSweeney Sean
Macromolecular Crystallography Group, European Synchrotron Radiation Facility, B.P. 220, 6 rue Jules Horowitz, F-38043, Grenoble-Cedex 9, France.
Mol Cell. 2006 Apr 21;22(2):149-50. doi: 10.1016/j.molcel.2006.04.001.
Helicases are molecular motors known to unwind double-stranded DNA. In a recent issue of Molecular Cell, Fan et al. (2006) revealed the core structure of XPB helicase, a component of transcription factor IIH, and proposed a mechanism for its dual role in transcription and nucleotide excision repair.
解旋酶是已知能解开双链DNA的分子马达。在最近一期的《分子细胞》杂志上，范等人（2006年）揭示了转录因子IIH的一个组成部分XPB解旋酶的核心结构，并提出了其在转录和核苷酸切除修复中发挥双重作用的机制。
