Lagunas-Solar M C, Kiefer P M, Carvacho O F, Lagunas C A, Cha Y P
Radioisotope Program, Crocker Nuclear Laboratory University of California, Davis 95616.
Int J Rad Appl Instrum A. 1991;42(7):643-57. doi: 10.1016/0883-2889(91)90035-y.
The direct production of no-carrier-added (NCA) 6.02 h 99mTc and of 66 h 99mMo using proton beams of natural Mo targets was investigated. The major objective of this work was to evaluate the potential of utilizing high-intensity proton accelerators as a supply source of 99mTc and 99Mo for use in diagnostic nuclear medicine. The excitation functions for the production of the directly-made 99mTc via the 100Mo(p, 2n)99mTc (Q = -7.85 MeV) reaction, and of its parent 99Mo via the 100Mo(p, pn) 99Mo (Q = -8.30 MeV) and 100Mo(p, 2p)99mNb(15 s)----99Mo (Q = -11.14 MeV) reactions, were measured in the 68-8 MeV energy range. Single and cumulative yields for 99mTc and 99Mo, and for other Tc, Mo, Zr, Nb and Y radiocontaminants were also determined. The prospects of integrating the use of enriched 100Mo targets with high-intensity, dual beam, H- accelerators was analyzed. The potential of this combined method to replace or complement the current reactor-based supply sources of 99Mo----99mTc generators, is also discussed. Finally, a brief analysis is made on the potential use of this combined technology to support the anticipated expansion of nuclear medicine in developing nations.
研究了使用天然钼靶的质子束直接生产无载体添加（NCA）的6.02小时99mTc和66小时99mMo。这项工作的主要目标是评估利用高强度质子加速器作为99mTc和99Mo的供应源用于诊断核医学的潜力。通过100Mo(p, 2n)99mTc（Q = -7.85 MeV）反应直接生产99mTc，以及通过100Mo(p, pn) 99Mo（Q = -8.30 MeV）和100Mo(p, 2p)99mNb(15 s)----99Mo（Q = -11.14 MeV）反应生产其母体99Mo的激发函数，在68 - 8 MeV能量范围内进行了测量。还测定了99mTc和99Mo以及其他Tc、Mo、Zr、Nb和Y放射性污染物的单产和累积产额。分析了将富集的100Mo靶与高强度双束H - 加速器结合使用的前景。还讨论了这种组合方法替代或补充当前基于反应堆的99Mo - 99mTc发生器供应源的潜力。最后，简要分析了这种组合技术在支持发展中国家核医学预期扩张方面的潜在用途。
