Karakaya Osman, Saglam Mustafa, Barutcu Irfan, Esen Ali Metin, Turkmen Muhsin, Kargin Ramazan, Esen Ozlem, Ozdemir Nihal, Kaymaz Cihangir
Department of Cardiology, Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey.
J Electrocardiol. 2007 Apr;40(2):203-6. doi: 10.1016/j.jelectrocard.2005.10.009. Epub 2006 Feb 28.
Isolated coronary ectatic but otherwise normal epicardial coronary arteries are an infrequent angiographic finding. We sought to determine whether coronary artery ectasia (CAE) may alter QT-interval duration and dispersion. The study population consisted of 24 patients with isolated CAE and otherwise normal epicardial coronary arteries (group 1) and sex- and age-matched subjects with atypical chest pain and otherwise normal coronary flow (group 2). Both groups underwent a routine standard 12-lead surface electrocardiogram recorded at 50 mm/s during rest. QT dispersion (QTd), corrected QT (QTc), and corrected QT dispersion (QTcd) were calculated. Distribution of sex, age, body mass index, and cardiac risk factors were similar in the 2 groups. Mean heart rate was similar in the 2 groups (74 +/- 10 vs 70 +/- 7, P > .05). In group 1, QTd, QTcd, and QTc were significantly higher than those of group 2 (QTd, 40 +/- 17 vs 29 +/- 10 milliseconds [P < .05]; QTcd, 43 +/- 19 vs 30 +/- 10 milliseconds [P < .05]; QTc, 410 +/- 21 vs 397 +/- 19 milliseconds [P < .05]). In conclusion, CAE was found to be associated with prolonged QT interval and increased QTd. Microvascular dysfunction and/or ischemia may be responsible mechanisms.
孤立性冠状动脉扩张但其他方面正常的心外膜冠状动脉是一种罕见的血管造影表现。我们试图确定冠状动脉扩张（CAE）是否会改变QT间期时长和离散度。研究人群包括24例孤立性CAE且心外膜冠状动脉其他方面正常的患者（第1组）以及年龄和性别匹配、有非典型胸痛且冠状动脉血流其他方面正常的受试者（第2组）。两组均在静息状态下以50mm/s记录常规标准12导联体表心电图。计算QT离散度（QTd）、校正QT（QTc）和校正QT离散度（QTcd）。两组的性别、年龄、体重指数和心脏危险因素分布相似。两组的平均心率相似（74±10比70±7，P>.05）。在第1组中，QTd、QTcd和QTc显著高于第2组（QTd，40±17比29±10毫秒[P<.05]；QTcd，43±19比30±10毫秒[P<.05]；QTc，410±21比397±19毫秒[P<.05]）。总之，发现CAE与QT间期延长和QTd增加有关。微血管功能障碍和/或缺血可能是其机制。
