FLT3抑制剂KRN383对急性髓系白血病中携带FLT3激活突变FLT3的异种移植人白血病细胞的作用：关于生物学特性和最佳靶向还有很多需要了解的地方。
FLT3 inhibitor KRN383 on xenografted human leukemic cells harboring FLT3-activating mutations FLT3 in AML: much more to learn about biology and optimal targeting.
作者信息
Giles Francis J
出版信息
Leuk Res. 2006 Dec;30(12):1469-70. doi: 10.1016/j.leukres.2006.03.002. Epub 2006 May 2.
Abstract
Aberrant FLT3 function in leukemia blasts is associated with a poor prognosis. A number of FLT3 modulators are in development. FLT3 mutations may synergistize with other molecular abnormalities in myeloid transformation. Further insights into FLT3 biology are needed to optimally study the therapeutic role of FLT3 inhibitors.
摘要
白血病母细胞中异常的FLT3功能与预后不良相关。多种FLT3调节剂正在研发中。FLT3突变可能在髓系转化中与其他分子异常协同作用。需要对FLT3生物学有更深入的了解，以优化研究FLT3抑制剂的治疗作用。
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