Walz Jochen, Graefen Markus, Chun Felix K-H, Erbersdobler Andreas, Haese Alexander, Steuber Thomas, Schlomm Thorsten, Huland Hartwig, Karakiewicz Pierre I
Department of Urology, University Medical Centre Eppendorf, Hamburg, Germany.
Eur Urol. 2006 Sep;50(3):498-505. doi: 10.1016/j.eururo.2006.03.026. Epub 2006 Mar 29.
We explored the yield of saturation biopsy and developed a nomogram predicting the probability of prostate cancer (PCa) on the basis of saturation biopsy.
Between 2001 and 2004, saturation biopsies (average of 24 cores) were performed in 161 men with persistently elevated prostate specific antigen (PSA) level (median, 9 ng/ml). All had at least two previously negative, eight-core biopsy sessions. PCa predictors on saturation biopsy were integrated within multivariate nomograms.
PCa detection was 41% (n=66 of 161). PSA density and transition zone volume were the most significant predictors of PCa on saturation biopsy. The accuracy of the nomogram with the best performance characteristics was 72%.
Saturation biopsy may be indicated in men with a persistent suspicion of PCa. High-risk individuals can be identified accurately with our nomogram.
我们探讨了饱和活检的检出率，并基于饱和活检开发了一种预测前列腺癌（PCa）概率的列线图。
在2001年至2004年期间，对161名前列腺特异性抗原（PSA）水平持续升高（中位数为9 ng/ml）的男性进行了饱和活检（平均24针）。所有患者此前至少有两次八针活检结果均为阴性。将饱和活检时的PCa预测因素纳入多变量列线图。
PCa检出率为41%（161例中有66例）。PSA密度和移行区体积是饱和活检时PCa的最显著预测因素。性能最佳的列线图的准确率为72%。
对于持续怀疑患有PCa的男性，可能需要进行饱和活检。使用我们的列线图可以准确识别高危个体。
