O'Brien R T, Hendrick M J, Evans S M, Brooks J J
Department of Clinical Studies, School of Veterinary Medicine, Hospital of the University of Pennsylvania, Philadelphia.
J Comp Pathol. 1991 Nov;105(4):423-30. doi: 10.1016/s0021-9975(08)80111-9.
Widespread organ distribution of malignant fibrous histiocytoma, including osseous involvement, was demonstrated in two dogs. Both cases had a storiform-pleomorphic pattern histologically and immunohistochemical stains were used to differentiate this from other types of neoplasms with the same histological pattern. Radiographically the lesions were predominantly lytic in the metaphysis of long bones, although periosteal proliferation and axial skeletal involvement were seen in one dog.
