伪狂犬病病毒在猪气管器官培养物中的感染发病机制。
Pathogenesis of Aujeszky's disease virus infection in swine tracheal organ culture.
作者信息
Narita M, Imada T, Kobayashi M
机构信息
National Institute of Animal Health, Ibaraki, Japan.
出版信息
J Comp Pathol. 1991 Nov;105(4):439-44. doi: 10.1016/s0021-9975(08)80113-2.
Two different strains of Aujeszky's disease virus (ADV) were inoculated into swine tracheal organ culture. Both viruses replicated in and destroyed the tracheal epithelium and epithelial cells. ADV antigen was first localized in ciliated epithelial cells by fluorescent antibody and immunoperoxidase examinations. Corresponding to the distribution of ADV antigen, many ADV particles were observed in ciliated epithelial cells. Results demonstrated that the tracheal epithelium infected with ADV is reduced in its ciliary activity.
将两种不同毒株的伪狂犬病病毒（ADV）接种到猪气管器官培养物中。两种病毒均在气管上皮和上皮细胞中复制并将其破坏。通过荧光抗体和免疫过氧化物酶检测，首先在纤毛上皮细胞中定位到ADV抗原。与ADV抗原的分布相对应，在纤毛上皮细胞中观察到许多ADV颗粒。结果表明，感染ADV的气管上皮的纤毛活性降低。
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