兔角膜器官培养中的实验性疱疹性角膜炎
Experimental herpetic keratitis in rabbit corneal organ cultures.
作者信息
Percy D H, Creighton M O, Hatch L A, De Clercq E
出版信息
Br J Exp Pathol. 1984 Feb;65(1):41-9.
An in-vitro method for maintaining rabbit corneal organ cultures for short periods of time is described. These cultures supported replication of strains of type 1 and 2 herpes simplex virus, and changes typical of herpetic infections of the cornea in vivo were observed by light microscopy, and by scanning and transmission electron microscopy. Infectious virus was readily recovered from inoculated corneal organ cultures. For practical, economic and humanitarian reasons, the full potential of this system warrants further investigation.
本文描述了一种在体外短时间维持兔角膜器官培养物的方法。这些培养物支持1型和2型单纯疱疹病毒毒株的复制，通过光学显微镜、扫描电子显微镜和透射电子显微镜观察到了体内角膜疱疹感染的典型变化。从接种的角膜器官培养物中很容易回收感染性病毒。出于实际、经济和人道主义原因，该系统的全部潜力值得进一步研究。
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