Nodera Hiroyuki, Kaji Ryuji
Department of Neurology, Graduate School of Medicine, Tokushima University, 2-50-1 Kuramoto, Tokushima 770-8503, Japan.
Clin Neurophysiol. 2006 Sep;117(9):1902-16. doi: 10.1016/j.clinph.2006.01.018. Epub 2006 Apr 24.
Non-invasive nerve excitability testing measures the membrane polarization, ion channel function and paranodal/internodal condition of peripheral nerves. This technique has been recently used for various neuromuscular disorders, such as pure motor conduction block in multifocal motor neuropathy, conduction block in carpal tunnel syndrome and Na(+) channel function disorders in diabetic neuropathy, to shed light on their pathophysiology. Here, we review the basics of ion channel functions and membrane properties that influence nerve excitability, the basic principles of nerve excitability testing and the reported findings in various disorders.
非侵入性神经兴奋性测试可测量外周神经的膜极化、离子通道功能以及结旁/结间状态。该技术最近已被用于多种神经肌肉疾病，如多灶性运动神经病中的纯运动传导阻滞、腕管综合征中的传导阻滞以及糖尿病性神经病中的钠通道功能障碍，以阐明其病理生理学机制。在此，我们综述影响神经兴奋性的离子通道功能和膜特性的基础知识、神经兴奋性测试的基本原理以及在各种疾病中的报道结果。
