Rees William D, Hay Susan M, Cruickshank Morven, Reusens Brigitte, Remacle Claude, Antipatis Christos, Grant George
Division of Energy Balance and Obesity, The Rowett Research Institute, Greenburn Rd, Bucksburn, AB21 9SB Aberdeen, UK.
Metabolism. 2006 May;55(5):642-9. doi: 10.1016/j.metabol.2005.12.006.
Evidence to support an association between early nutrition and the development of obesity in the rat is equivocal. In this study we have investigated the postnatal growth, glucose tolerance, and adipocyte function of the offspring from pregnant rats fed with diets containing either 20% or 8% protein during gestation. By 25 weeks of age, the female offspring of dams fed with the diet containing 8% protein had a significantly lower adult body weight due in part to a decrease in body fat. The peak concentration of insulin after oral administration of a glucose dose was significantly lower in both the male and female offspring of the dams fed with the diet containing 8% protein. However, the ability of insulin to stimulate lipogenesis or suppress lipolysis in fat cells isolated from the offspring was not influenced by the prenatal diet. Hepatic phosphoenolpyruvate carboxykinase activity was reduced in female offspring of dams fed with the diet containing 8% protein. These results show that adult body composition is determined during the prenatal period as a result of programming of the insulin axis. This metabolic programming influences hepatic metabolism; however, there is no evidence for a programmed change in adipocyte function.
支持早期营养与大鼠肥胖发展之间存在关联的证据并不明确。在本研究中，我们调查了孕期喂食含20%或8%蛋白质饮食的孕鼠所产后代的出生后生长、葡萄糖耐量和脂肪细胞功能。到25周龄时，喂食含8%蛋白质饮食的母鼠所生雌性后代的成年体重显著降低，部分原因是体脂减少。口服葡萄糖后，喂食含8%蛋白质饮食的母鼠所生雄性和雌性后代的胰岛素峰值浓度均显著降低。然而，胰岛素刺激后代分离出的脂肪细胞中脂肪生成或抑制脂肪分解的能力不受产前饮食的影响。喂食含8%蛋白质饮食的母鼠所生雌性后代的肝磷酸烯醇式丙酮酸羧激酶活性降低。这些结果表明，成年身体组成在产前时期就已通过胰岛素轴的编程而确定。这种代谢编程会影响肝脏代谢；然而，没有证据表明脂肪细胞功能会发生程序性变化。
